Nurofen (ibuprofen) alters testicular physiology

2024 Author: Seth Attwood | [email protected]. Last modified: 2023-12-16 15:55

Regular use of generic over-the-counter pain relievers such as Ibuprofen (which is part of Nurofen) can be harmful and contribute to male infertility and impotence … This conclusion was made by the authors of the study "Ibuprofen changes the physiology of the testicles, reducing the production of male sex hormones."

Ibuprofen is a drug marketed as an anti-inflammatory drug that has analgesic and antipyretic effects. It is the active ingredient of the pain reliever NUROFEN, which is popular in Russia. Other trade names: Advil, Bonifen, Brufen SR, Burana, Dolgit, Ibalgin, Ibunorm, Ibuprom, Ibufen, MIG 400 (Imet), Nurofen, Solpaflex, Faspik.

A new study published in the PNAS journal of the US National Academy of Sciences has shown that regular use of ibuprofen can be harmful. This condition of decreased male hormone production, which can lead to infertility, erectile dysfunction, depression, and loss of bone and muscle mass, is called compensated hypogonadism.

Earlier studies on the harm of ibuprofen to men

Previously, a similar study of painkillers was already conducted on 90 thousand men aged 45 to 69 years and it showed that people who regularly took aspirin ibuprofen (Advil, Motrin), naproxen (Aleve, Anaprox, Naprosyn) and other NSAIDs 38% more likely to suffer from erection problems.

The study was conducted on 31 healthy young people aged 18 to 35 years. Fourteen men took two 600-milligram doses of ibuprofen over six weeks - the amount many athletes take to relieve pain. The other 17 people took placebo pills.

results

Both groups of men underwent blood tests and hormone tests throughout the study. After 14 days of ibuprofen use, researchers observed higher blood levels of luteinizing hormone, which regulates the production of testosterone and other hormones. After 44 days, the levels were even higher. However, testosterone production did not increase concurrently, resulting in a lower testosterone to luteinizing hormone ratio - a sign of testicular failure, according to the article.

The researchers also observed other hormonal disturbances at 14 and 44 days of ibuprofen consumption, which indicated the widespread consequences of suppression of testicular function.

The researchers then tested the direct effect of the substance on the testes using samples taken from organ donors. For exposure to ibuprofen levels similar to those taken orally, testicular samples produced less testosterone after 24 hours … The researchers found that the higher and longer the exposure, the more dramatic the effect. It was found that also gene function is disruptedassociated with the conversion of cholesterol into steroid hormones.

Dangers of taking painkillers by pregnant women, men and children

Previous research by the lead author has also shown that boys born to mothers who took ibuprofen during the first trimester of pregnancy can impair testicular development. This means that, in at least some scenarios, the drug can negatively affect male virility later on.

Earlier publications confirm this as well. In them, taking ibuprofen, aspirin and paracetamol during pregnancy in 2300 Finnish and Danish women increased the risk of cryptorchidism (testicular pathology) in boys by 16 times. Taking painkillers in the second trimester of pregnancy is especially unfavorable: they disrupt the formation of the genitals and the production of testosterone. And in the absence of treatment, in the future it can cause infertility in men, and possibly affect the phenomenon of "transgender".

In addition, there are studies showing an increased risk of heart disease and heart attack in connection with taking the drug.

The discovered harm of Ibuprofen, as an indicator of mass irresponsibility

This once again confirms the low level of safety of even advertised drugs and their analogues. After all, before these studies, Ibuprofen was (and still continues to be) included in the WHO list of essential medicines, as well as in the list of vital and essential medicines, approved by the order of the Government of the Russian Federation of 2009-30-12 No. 2135-r

In more than 50 years since its synthesis in 1962, especially after it received OTC status in 1983, HUNDREDS OF MILLIONS of women and men have used this drug in one form or another! According to Wikipedia, by the end of 1985 more than 100 million people were using Nurofen.

How could this affect people? We can see that during this same period there is a sharp increase in all kinds of "blurring of boundaries" between the sexes, which were not foreseen by nature before.

And if it took more than 50 years to check whether a drug is harmful, then what can we say about those drugs that appear every day and are sold in huge volumes? It is UNKNOWN to the end what consequences they have, even in the medium term, not to mention the long term. Especially children and pregnant women. And no one can guarantee the safety of drugs that affect the structure of the body and the genome.

Therefore, THINK FOR YOURSELF what you are accepting. And let your friends, and especially girlfriends, so that they understand this too.